September 10, 2025Cell ReportsOpen Access

A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis

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Discussion

Single-cell analyses reveal unique multipotent progenitors in adult bone marrow, indicating functional diversity.

Distinct multipotent progenitors were identified within adult human bone marrow, enhancing understanding of hematopoiesis.
A CD69+ multipotent progenitor showed long-term engraftment and potential for multilineage differentiation.
Multi-omic single-cell analyses were employed to prospectively isolate various human multipotent progenitor populations.
Findings highlight cell-type-specific changes in hematopoiesis associated with human aging and species homology.

Ediriwickrema et al. (2025) studied this question.

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