July 21, 2025Open Access

A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche.

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New reporter strategy identifies non-migratory hematopoietic stem cells in a dynamic bone marrow niche, suggesting unique niche dynamics.

Hoxb5+Vwf+ cells are a subset of long-term hematopoietic stem cells crucial for regulation in homeostasis and ageing.
Intravital microscopy shows these cells are non-migratory, even during stress when they proliferate.
The double reporter strategy provides stable identification of HSCs, overcoming limitations of previous methods.
Findings reveal niche dynamics that influence hematopoietic stem cell behavior during regeneration and stress.

Secchi et al. (2025) studied this question.

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