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November 30, 2025Journal of Personalized MedicineOpen Access

The Heterogeneous Interplay Between Metabolism and Mitochondrial Activity in Colorectal Cancer

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Authors

CDChristophe DesterkeYFYuanji FuJGJorge Mata Garrido

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Overview

Analysis reveals metabolism and mitochondrial activities influence colorectal cancer subtype responses, suggesting predictive markers for therapy.

Key Points

  • Colorectal cancer shows distinct metabolic responses across various subtypes, highlighting its complexity.
  • Machine learning identified metabolism/mitochondrial scores as predictive biomarkers for specific gene mutations.
  • Single-cell RNA-sequencing revealed how metformin alters metabolism and mitochondrial activity in colorectal tumors.
  • Immune checkpoint blockade responses differ based on the metabolic and mitochondrial states of the tumors.

Cite This Study

Desterke et al. (2025) studied this question.

synapsesocial.com/papers/692b9da91d383f2b2a37a676https://doi.org/10.3390/jpm15120571
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