Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns

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This review presents a comprehensive analysis of inflammasome mechanisms and their implications for regulating cytokine release in immune responses.

Inflammasome activation leads to the secretion of proinflammatory cytokines, including IL-1β and IL-18.
Key inflammasome types include NLRP1, NLRP3, NAIP-NLRC4, AIM2, contributing to various immune responses.
The study emphasizes the role of caspase-1 in pyroptosis, which affects innate and adaptive immunity.
Insights into inflammasome signaling pathways may reveal novel therapeutic targets for diseases.

Dubey et al. (2025) studied this question.

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This review presents a comprehensive analysis of inflammasome mechanisms and their implications for regulating cytokine release in immune responses.