Immuno-metabolic diseases and therapeutics: molecular mechanisms via inflammasome signaling

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Review updates the role of inflammasomes in metabolic diseases, highlighting their potential as therapeutic targets.

Inflammasome activation contributes to chronic inflammation and metabolic diseases such as obesity and diabetes.
Key cytokines, including interleukin-1β and interleukin-18, drive inflammation and tissue damage.
This review focuses on the NLRP3 inflammasome and its role in insulin resistance and metabolic dysfunction.
Emerging data suggest targeting inflammasomes may help mitigate chronic inflammation and improve metabolic health.

Joo‐Hui Han (2025) studied this question.

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