August 15, 2025PeerJOpen Access

NLRP3 inflammasome and pyroptosis: implications in inflammation and multisystem disorders

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Discussion

This review reveals the nlrp3 inflammasome's role in inflammation and pyroptosis in various diseases, highlighting therapeutic targets.

NLRP3 inflammasome activation induces pyroptosis, which is crucial in immune and inflammatory responses.
NLRP3 inhibitors like MCC950 have protective effects in inflammatory diseases, suggesting therapeutic promise.
This review synthesizes the role of the nlrp3 inflammasome and pyroptosis across different physiological systems.
Understanding these mechanisms may empower new therapeutic strategies for managing inflammatory disorders.

Li et al. (2025) studied this question.

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