September 5, 2025Frontiers in ImmunologyOpen Access

NLRP3 and beyond: inflammasomes as central cellular hub and emerging therapeutic target in inflammation and disease

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This review discusses how activating the NLRP3 inflammasome affects cytokine release in inflammation, suggesting novel therapeutic targets.

Increased NLRP3 activation leads to heightened pyroptosis, contributing to various diseases like neurodegeneration and infection.
Dysregulation of regulatory mechanisms can escalate inflammatory responses, indicating critical checkpoints for therapeutic intervention.
Emerging small molecules show promise in neutralizing inflammasome pathways, especially in preclinical models involving inflammatory diseases.
Understanding diverse inflammasome functions could enhance precision immunotherapy strategies for chronic inflammation.

Fernández et al. (2025) studied this question.

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This review discusses how activating the NLRP3 inflammasome affects cytokine release in inflammation, suggesting novel therapeutic targets.