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October 9, 2025Circulation Research

Abstract Thu152: Sex-Specific Cardiometabolic Crosstalk with Adipose Tissue in Transgenic Mice

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Authors

AIAmanda IfftIMIyad H. ManaserhKBKamila Bledzka

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Overview

Observational analysis reveals sex-specific cardiometabolic profiles in transgenic mice on high-fat diet, suggesting implications for metabolic health.

Key Points

  • Males on a high-fat diet showed better cardiac health and adipose function, while females experienced dysfunction and impaired signaling.
  • By 16 weeks, male mice had 3,701 ng/mL α-amino acid stereoisomer, while females had 6,042 ng/mL, indicating significant genotype-dependent differences.
  • Analysis involved serum metabolomics using HPLC-MS, assessing metabolite changes over time in high-fat diet mice compared with littermate controls.
  • Understanding these sex-specific changes may highlight novel therapeutic targets for obesity and associated metabolic disorders.

Cite This Study

Ifft et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877df1https://doi.org/10.1161/res.137.suppl_1.thu152
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A-052 Sex-Specific Cardiometabolic Crosstalk with Adipose Tissue in Transgenic Mice2025
  2. 2Abstract Fri154: GRK2-mediated cardiomyocyte signaling factors are responsible for alterations in adiposity and mediate heart-fat communication2025
  3. 3The metabolic response to high fat intake depends on dietary fatty acid composition and sex2025
  4. 4Abstract Wed097: Metabolic Syndrome in Rodents Activates β-adrenergic Receptor Signaling Concealing Defects in Cardiac Performance2025
  5. 5Sex-Dependent Cardiac Responses to β3-Adrenergic Receptor Activation in a Murine Model of Heart Failure with Preserved Ejection Fraction2026