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October 3, 2025Clinical ChemistryOpen Access

A-052 Sex-Specific Cardiometabolic Crosstalk with Adipose Tissue in Transgenic Mice

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Authors

AIAmanda IfftIMIyad H. ManaserhKBKamila Bledzka

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Overview

Analysis shows differential effects of cardiokines on adipose tissue in male and female transgenic mice, suggesting unique metabolic adaptations.

Key Points

  • Female transgenic mice exhibited reduced cardiometabolic signaling and dysfunction under high-fat diet stress.
  • Male transgenic mice demonstrated enhanced metabolic flexibility and improved white adipose tissue health by 16 weeks.
  • Targeted metabolomics analysis revealed sex-specific concentration differences in metabolites related to cardiac metabolism.
  • These findings highlight potential therapeutic targets for obesity and metabolic dysfunction through understanding adipose tissue crosstalk.

Cite This Study

Ifft et al. (2025) studied this question.

synapsesocial.com/papers/68e040e9a99c246f578b30ebhttps://doi.org/10.1093/clinchem/hvaf086.051
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