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October 10, 2025Circulation Research

Abstract Wed097: Metabolic Syndrome in Rodents Activates β-adrenergic Receptor Signaling Concealing Defects in Cardiac Performance

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Authors

GPGiulia PiccininiUniversity of ParmaDCDaniel O. CervantesNew York Medical CollegeMSMichael G. SunSUNY Upstate Medical University

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Implication

Metabolic syndrome alters cardiac performance in C57Bl/6 mice, suggesting β-adrenergic signaling plays a key role.

Key Points

  • Metabolic syndrome exacerbates heart rate variations, indicating sympathoexcitation in the heart.
  • Inhibition of β-adrenergic receptors normalizes heart rates in mice with metabolic syndrome.
  • Echocardiographic analysis shows no baseline differences in cardiac function until β-AR blockade.
  • Left ventricular myocytes from metabolic syndrome mice exhibit increased cell shortening, revealing hidden cardiac dysfunction.

Cite This Study

Piccinini et al. (2025) studied this question.

synapsesocial.com/papers/68e861a57ef2f04ca37e47b9https://doi.org/10.1161/res.137.suppl_1.wed097
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered β-Adrenergic System, Cardiac Dysfunction, and Lethal Arrhythmia in a Rat Model of Metabolic Syndrome2025 · 1 citations
  2. 2Abstract Thu152: Sex-Specific Cardiometabolic Crosstalk with Adipose Tissue in Transgenic Mice2025
  3. 3A-052 Sex-Specific Cardiometabolic Crosstalk with Adipose Tissue in Transgenic Mice2025
  4. 4Abstract Fri154: GRK2-mediated cardiomyocyte signaling factors are responsible for alterations in adiposity and mediate heart-fat communication2025
  5. 5Abstract Wed016: Loss of β 2 Adrenergic Receptor S-nitrosylation Protects Against Myocardial Injury2025