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July 22, 2026BiomedicinesOpen Access

Mirabegron attenuates cardiac remodeling in male mice with HFpEF, but less so in females.

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Why the study?

Does mirabegron improve cardiac remodelling in a murine model of HFpEF?

Population

Male and female C57BL/6J mice exposed to metabolic and hypertensive stress to induce a model of heart…

Comparison

Mirabegron 2 mg/kg/day for 28 days. vs No mirabegron treatment.

Design

Preclinical

Follow-up

28 days

Key result

Mirabegron attenuated cardiac hypertrophy, left atrial enlargement, and left ventricular dilation in male mice with HFpEF, whereas females exhibited a less pronounced response.

Authors

STSara-Ève ThibodeauÉWÉlisabeth Walsh‐WilkinsonELEmylie-Ann Labbé

Discussion

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Overview

Sex-specific β3-AR effects on murine remodeling are hypothesis-generating; should not yet change clinical practice or trial design.

Key Points

  • This research aims to examine how the activation of β3-adrenergic receptors influences cardiac changes in heart failure, focusing on sex differences.
  • C57BL/6J mice (male and female) were subjected to metabolic and hypertensive stress for 28 days.
  • Mirabegron was administered at a dose of 2 mg/kg/day to evaluate its effects on cardiac structure and function.
  • Cardiac assessments included echocardiography, molecular, and histological analyses of cardiac and brown adipose tissue.
  • Mirabegron reduced cardiac hypertrophy, left atrial enlargement, and left ventricular dilation in males.
  • There was decreased expression of hypertrophy and fibrosis-related genes in males, while females showed a less marked response.
  • Males exhibited a significant increase in brown adipose tissue mass and thermogenic gene expression (Ucp1) compared to females.

Structured PICO

Does mirabegron improve cardiac remodelling in a murine model of HFpEF?

P
Population
Male and female C57BL/6J mice exposed to metabolic and hypertensive stress for 28 days to induce HFpEF.
I
Intervention
Mirabegron 2 mg/kg/day for 28 days.
C
Comparator
No mirabegron treatment (exposed to metabolic and hypertensive stress only).
O
Outcome
Cardiac structure and function assessed by echocardiography, and molecular and histological analyses on cardiac and brown adipose tissues.surrogate

Pharmacological activation of β3-AR with mirabegron attenuates cardiac remodelling in a sex-dependent manner in a murine HFpEF model, with greater protective effects observed in males.

Limitations

  • Causality between BAT activation and cardiac remodelling was not directly demonstrated

Cite This Study

Thibodeau et al. (2026) studied Heart failure with preserved ejection fraction (HFpEF). Mirabegron vs. No mirabegron treatment was evaluated on Cardiac remodelling (cardiac hypertrophy, left atrial enlargement, and left ventricular dilation). Mirabegron attenuated cardiac hypertrophy, left atrial enlargement, and left ventricular dilation in male mice with HFpEF, whereas females exhibited a less pronounced response.

synapsesocial.com/papers/6a605dd44163e025518d7b87https://doi.org/10.3390/biomedicines14071633
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