Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
October 9, 2025Circulation Research

Abstract Thu111: The splicing factor SF3B1 in regulating endothelial gene expression and angiogenesis

View Full Paper
Ask AI
Bookmark
Share

Authors

ZLZiqing Liu

Discussion

Loading...

Member takes

Overview

This study demonstrates that SF3B1 regulates angiogenesis in endothelial cells, indicating its critical role in gene expression.

Key Points

  • SF3B1 is essential for EC proliferation and survival, underpinning regulatory roles in angiogenesis.
  • Knocking down SF3B1 resulted in disrupted angiogenesis and mis-splicing of over 30% of the transcriptome.
  • Using a new Sf3b1 floxed mouse line, impaired angiogenesis was observed in EC-specific knockout (iECKO) during development.
  • Analysis highlighted the need for consideration of vascular toxicity in therapies targeting splicing factors like SF3B1.

Cite This Study

Ziqing Liu (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877dc6https://doi.org/10.1161/res.137.suppl_1.thu111
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial SRSF1 regulates hematopoietic stem cell function in the bone marrow microenvironment2025
  2. 2SF3B1 mutations K700E, K666N, and R625H: Gene expression and aberrant splicing consequences2025
  3. 3Novel therapeutics for SF3B1 mutant cancers which exploit the missplicing of DCAF162025 · 1 citations
  4. 4ELK1 modulates SF3B3 transcriptional activity to stimulate proliferation and inhibit apoptosis in gastric cancer through the activation of the MAPK pathway2025
  5. 5Splicing factor Sf3b1 facilitates maintenance of neuronal dendrites by modulating mitochondrial health2025