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October 9, 2025Cellular and Molecular Life SciencesOpen Access

Splicing factor Sf3b1 facilitates maintenance of neuronal dendrites by modulating mitochondrial health

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Authors

WTWei‐Chia TsaoYHYi‐Chun HuangHSHsin-Ho Sung

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Overview

Genetic analysis reveals Sf3b1's role in maintaining mitochondrial function in neurons, indicating a link to dendritic growth.

Key Points

  • Sf3b1 is crucial for maintaining mitochondrial health, as its knockdown leads to mitochondrial fragmentation and reduced ATP levels.
  • Alterations in splicing patterns of mitochondria-related genes were observed, impacting energy supply for neuronal dendrite growth.
  • Through genetic screening, a connection between RNA splicing and mitochondrial demand in neurons was established, shedding light on metabolic pathways.
  • Mitophagy-modulating molecules can restore mitochondrial health and dendritic arborization in Sf3b1-depleted neurons.

Cite This Study

Tsao et al. (2025) studied this question.

synapsesocial.com/papers/68e79cf2ed88661f66c2e320https://doi.org/10.1007/s00018-025-05860-0
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  1. 1Abstract Thu111: The splicing factor SF3B1 in regulating endothelial gene expression and angiogenesis2025
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  4. 4Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity2025
  5. 5Novel therapeutics for SF3B1 mutant cancers which exploit the missplicing of DCAF162025 · 1 citations