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December 8, 2025Blood

Endothelial SRSF1 regulates hematopoietic stem cell function in the bone marrow microenvironment

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Authors

KBKruti BosmiaCCCody Carter

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Overview

Conditional Srsf1 knockout in endothelial cells leads to increased white blood cells in peripheral blood, suggesting altered hematopoietic output.

Key Points

  • HSC mobilization seen in Srsf1 knockout mice, leading to increased white blood cell counts and decreased bone marrow cellularity.
  • Srsf1iECKO mice displayed a 24-fold increase in circulating immunophenotypic HSCs, indicating potential relocalization of stem cells.
  • Assessment methods included Evan's blue dye assay for vascular permeability and blood pressure measurements, showing no significant vascular leakage.
  • Findings show the critical role of endothelial SRSF1 in regulating HSC homeostasis and suggest implications for targeted therapies in hematological disorders.

Cite This Study

Bosmia et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df71https://doi.org/10.1182/blood-2025-4966
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sf3b1+/K700E hematopoietic stem cells create their own expansion niche2025
  2. 2Abstract Thu111: The splicing factor SF3B1 in regulating endothelial gene expression and angiogenesis2025
  3. 3SF3B1 mutations K700E, K666N, and R625H: Gene expression and aberrant splicing consequences2025
  4. 4Endothelial cell-derived thrombospondin-1 negatively affects hematopoietic function during aging2025
  5. 5Impact of different Sf3b1 mutations on hematopoietic function and erythropoiesis2025