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October 9, 2025Circulation Research

Abstract Fri020: Plasminogen Activator Inhibitor-1 Governs Vascular Aging

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Authors

AKAlireza KhoddammohammadiNorthwestern UniversityAKAnthony KalousdianMEMesut ErenNorthwestern University

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Implication

Genetic reduction of PAI-1 improves cardiovascular function in aging mice, suggesting new therapeutic avenues.

Key Points

  • Genetic reduction of PAI-1 was linked to a 20% increase in overall survival in mice.
  • PAI-1 overexpression resulted in heightened cardiovascular pathophysiology, worsening outcomes in aging.
  • Using L-NAME treatment, researchers assessed changes in blood pressure and vascular stiffness in models.
  • Pharmacological inhibition of PAI-1 reversed age-related increases in aortic pulse wave velocity.

Cite This Study

Khoddammohammadi et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877d5fhttps://doi.org/10.1161/res.137.suppl_1.fri020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasminogen activator inhibitor 1 promotes aortic aging–like pathophysiology in humans and mice2025 · 5 citations
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  3. 3Inflammatory Macrophage-derived Plasminogen Activator Inhibitor-1 Exacerbates Inflammation through Efferocytosis Inhibition2025
  4. 4Plasminogen Activator Inhibitor-1 Levels in Heart Failure Patients: A Cross-sectional Study2025
  5. 5A Contemporary Review of Plasminogen Activator Inhibitor Type 1: Structure, Function, Genetic Architecture, and Intracellular/Extracellular Roles2025 · 9 citations