September 11, 2025TH OpenOpen Access

A Contemporary Review of PAI-1: Structure/Function, Genetic Architecture, and Intracellular/Extracellular Roles

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PAI-1 is a critical regulator of the fibrinolytic system and thrombosis, influencing plasmin activation.
The conserved structure of PAI-1 is essential for its function, affecting processes related to cell death and signaling.
Intracellular and extracellular functions of PAI-1 have significant implications for angiogenesis and cancer biology.
Understanding PAI-1 roles could provide insights into various disease states beyond its classical role in fibrinolysis.

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This review highlights PAI-1's role in thrombosis and broader implications in cancer biology and cell processes.

Wortley et al. (2025) studied this question.

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