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September 12, 2025AgingOpen Access

Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice

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Authors

TOTakashi OhiraNKNaoyuki KawaoYMYuya Mizukami

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Overview

Observational analysis finds PAI-1 impacts muscle and bone loss in aging mice, suggesting key differences by sex.

Key Points

  • PAI-1 deficiency blunted aging-related decreases in muscle mass and strength in female mice, indicating a protective role.
  • Aging increased PAI-1 expression in skeletal muscles of both sexes, highlighting its potential impact on sarcopenia and osteoporosis.
  • Muscle and bone assessments compared 24-month-old mice to 6-month-old mice, revealing significant age-related changes.
  • Results point to a potential mechanistic link between PAI-1 and aging-related sarcopenia and osteopenia, particularly in females.

Cite This Study

Ohira et al. (2025) studied this question.

synapsesocial.com/papers/68d41bfb713b0b5dfea6508dhttps://doi.org/10.18632/aging.206318
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