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August 1, 2025Clinical and Translational DiscoveryOpen Access

Integrative analyses of single‐cell and bulk RNA sequencing reveal tumour microenvironment features associated with neoadjuvant immunochemotherapy response in oesophageal squamous cell carcinoma

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Authors

XWXianxian WuXYXiaoxing YeWJWei Ji

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Overview

Integration of single-cell and bulk RNA sequencing uncovers tumour microenvironment factors affecting neoadjuvant immunochemotherapy outcomes in oesophageal squamous cell carcinoma.

Key Points

  • The study reveals that the baseline tumour microenvironment in nonresponders lacks major histocompatibility complex II and has low CXCL13.
  • Profiling of 512,736 cells identified distinct immune cell and macrophage characteristics linked to treatment outcomes.
  • Integration of single-cell and bulk RNA sequencing data provides insights into immune and tumor cell interactions.
  • Findings may guide the development of tailored therapies for patients with oesophageal squamous cell carcinoma.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68af78207567bf4f94ff02cehttps://doi.org/10.1002/ctd2.70080
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