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September 5, 2025Open Access

Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity

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Authors

MSMonil ShahIGIlika GhoshLPLuca Pishos

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Overview

Correlative light and electron microscopy reveals structural changes in mitochondria, indicating their role in supporting synaptic plasticity.

Key Points

  • Structural remodeling of mitochondria near synapses supports energy demands during synaptic plasticity.
  • Increased mitochondrial length and area near dendritic spines correlate with heightened ATP production.
  • Deep-learning-based segmentations helped achieve high-resolution analyses of mitochondrial changes.
  • Findings highlight the importance of mitochondrial changes for sustaining network function in the brain.

Cite This Study

Shah et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d64779f76https://doi.org/10.1101/2025.08.27.672715
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