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August 23, 2025International Journal of Molecular SciencesOpen Access

Computational Splicing Analysis of Transcriptomic Data Reveals Sulforaphane Modulation of Alternative mRNA Splicing of DNA Repair Genes in Differentiated SH-SY5Y Neurons

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Authors

MLMaria LuiLCLuigi ChiricostaRIRenato Iori

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Overview

Computational analysis shows sulforaphane modulates alternative splicing of DNA repair genes in SH-SY5Y neurons, suggesting neuroprotective effects.

Key Points

  • Sulforaphane treatment influences alternative splicing events, indicating a role in mRNA regulation over DNA repair genes.
  • A total of 194 differential alternative splicing events were identified in SH-SY5Y neurons, pointing to significant changes in gene expression.
  • An RNA-seq-based splicing analysis pipeline was employed to investigate the transcriptomic effects of sulforaphane treatment.
  • These findings propose sulforaphane as a potential adjuvant that enhances neuronal health and protects against DNA damage.

Cite This Study

Lui et al. (2025) studied this question.

synapsesocial.com/papers/68af79a47567bf4f94ff169ahttps://doi.org/10.3390/ijms26178187
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