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October 9, 2025Circulation Research

Abstract Wed020: Controlled Rigth Ventricular Pressure Overload Can Rescue Left Ventricular Dysfunction by Promoting Biventricular Adaptive Hypertrophy

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Authors

MPMatteo PonzoniLZLibo ZhangJZJennifer J. Zhang

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Overview

This study demonstrates that pulmonary artery banding improves left ventricular function and promotes biventricular adaptive hypertrophy in a rat model of dilated cardiomyopathy.

Key Points

  • Left ventricular dysfunction was rescued following pulmonary artery banding, resulting in improved ejection fraction.
  • Positive remodeling was observed in treated rats, with significant decreases in end-diastolic volume and LV fibrosis.
  • Histological analysis revealed increased cardiomyocyte diameter and neoangiogenesis, highlighting structural adaptations.
  • Preserved phospholamban phosphorylation in treated rats suggests enhanced calcium cycling and contractility sustainability.

Cite This Study

Ponzoni et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fc0bhttps://doi.org/10.1161/res.137.suppl_1.wed020
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left ventricular pressure‐loading improves pressure‐induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling2025
  2. 2Reverse Remodeling in Pediatric Myocarditis With DCM Phenotype Impact of rASD and PAB2026
  3. 3Microvascular preservation and cardiomyocyte hyperplasia underlie adaptive right ventricle development in congenital heart disease-pulmonary arterial hypertension2025 · 1 citations
  4. 4Effect of left bundle branch area pacing on cardiac remodeling and function: propensity score matching with right ventricular pacing2025
  5. 5Role of NPPB for Recovery Post Ventricular Assist Device in Paediatric Dilated Cardiomyopathy: Single-Cell Multiomics2025