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October 23, 2025ESC Heart FailureOpen Access

Role of NPPB for recovery post ventricular assist device in paediatric dilated cardiomyopathy: Single‐cell multiomics

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Authors

YKYosuke KugoTKT KawamuraAHAkima Harada

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Overview

Single-cell analysis reveals association of elevated NPPB and BNP with improved left ventricular recovery in children with dilated cardiomyopathy.

Key Points

  • Elevated brain natriuretic peptide levels are linked to better recovery outcomes in children post ventricular assist device implantation.
  • Gene expression analysis showed significant differences between recovery and non-recovery groups, especially involving apoptosis pathways.
  • Single-nucleus sequencing techniques were utilized to assess the LV tissue from children with idiopathic dilated cardiomyopathy.
  • These findings suggest that elevated NPPB and BNP may support recovery, indicating potential for targeted therapies in paediatric patients.

Cite This Study

Kugo et al. (2025) studied this question.

synapsesocial.com/papers/68f9a0eb8ea8f2f37ee94b23https://doi.org/10.1002/ehf2.15430
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract Wed020: Controlled Rigth Ventricular Pressure Overload Can Rescue Left Ventricular Dysfunction by Promoting Biventricular Adaptive Hypertrophy2025
  2. 2Implementing a Programmatic Approach to Identify and Promote Ventricular Recovery in Pediatric Patients Supported With Ventricular Assist Devices2026 · 1 citations
  3. 3Reverse Remodeling in Pediatric Myocarditis With DCM Phenotype Impact of rASD and PAB2026
  4. 4A single-center experience with recovery of heart function in children following ventricular assist device support2025
  5. 5From support to recovery: the evolving role of LVAD in reversing heart failure2025