Microvascular preservation & cardiomyocyte hyperplasia underlie adaptive right ventricle development in congenital heart disease-pulmonary arterial hypertension

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Observational analysis highlights increased cardiomyocyte numbers and unchanged microvascular density in congenital heart disease-associated PAH.

Shunt lambs demonstrated significant right ventricular enlargement, supporting adaptive hypertrophy despite unchanged microvascular density.
At 4-6 weeks, shunt lambs had 37.1 g RV mass compared to 15.9 g in controls, showing a marked response to pulmonary arterial hypertension.
Increased cardiomyocyte hyperplasia was observed in shunt lambs, with cross-sectional areas significantly smaller than controls, indicating ongoing adaptations.
Distinct transcriptomic profiles in shunt RV suggest metabolic adjustments, highlighting the complexity of adaptive right ventricular development.

Smith et al. (2025) studied this question.

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View Full Paper

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Authors

Observational analysis highlights increased cardiomyocyte numbers and unchanged microvascular density in congenital heart disease-associated PAH.

Shunt lambs demonstrated significant right ventricular enlargement, supporting adaptive hypertrophy despite unchanged microvascular density.
At 4-6 weeks, shunt lambs had 37.1 g RV mass compared to 15.9 g in controls, showing a marked response to pulmonary arterial hypertension.
Increased cardiomyocyte hyperplasia was observed in shunt lambs, with cross-sectional areas significantly smaller than controls, indicating ongoing adaptations.
Distinct transcriptomic profiles in shunt RV suggest metabolic adjustments, highlighting the complexity of adaptive right ventricular development.

Smith et al. (2025) studied this question.

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