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October 9, 2025Circulation Research

Abstract Fri049: Exploring the Role of Interferon Responsive Neutrophils in the Development of HFpEF

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Authors

JWJennifer L. WallerMBMaegan L. BrockmanTSTriniti Scruggs

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Overview

This study explores neutrophil responses to interferon in heart failure with preserved ejection fraction, suggesting implications for inflammation.

Key Points

  • The study demonstrates that neutrophils' response to interferon impacts inflammation in a model of HFpEF.
  • Flow cytometry data indicate a significant modulation of inflammatory cell abundance due to knockout of the interferon receptor.
  • Surgical alterations indicate no significant change in cardiac function, despite differences in inflammatory markers.
  • HFpEF development was assessed in mice subjected to a high-fat diet, revealing insights into potential therapeutic targets.

Cite This Study

Waller et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fbd6https://doi.org/10.1161/res.137.suppl_1.fri049
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract Wed091: Biomechanical and Transcriptomic Remodeling of the Heart in Heart Failure with Preserved Ejection Fraction2025
  2. 2BS53 Neutrophil elastase: a novel therapeutic target for heart failure with preserved ejection fraction2025
  3. 3Abstract Wed089: Deciphering transcriptome and cell-cell communication signature in heart failure with preserved ejection fraction at single cell resolution2025
  4. 4Abstract Fri112: Mitochondrial Maladaptation at the Crossroads of Heart Failure: A Tale of Two Phenotypes2025
  5. 5Pharmacological clearance of senescent cells reduces inflammation, endothelial damage and cardiac fibrosis in HFpEF2025 · 13 citations