Abstract Wed092: Embracing the complex pathophysiology of heart failure with preserved ejection fraction by developing rodent models to feature different patients’ phenogroups.

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Discussion

Different rodent models mimic heart failure with preserved ejection fraction phenogroups, suggesting tailored therapy approaches.

Models highlight specific phenogroups associated with heart failure with preserved ejection fraction (HFpEF), enabling targeted research.
Empagliflozin positively impacted cardiac function in hamsters and other models, indicating potential therapeutic benefits.
Diastolic dysfunction varied among models, with distinct profiles observed in the metabolic syndrome hamster and diabetic rat models.
Findings emphasize the necessity for multiple models to optimize therapies for heart failure with preserved ejection fraction patients.

Assaly et al. (2025) studied this question.

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