NAD+ replenishment demonstrates improvement in cardiac function and reduces senescence in aged mice, suggesting therapeutic potential for heart failure.
Key Points
NAD+ replenishment reduced cardiomyocyte senescence and improved diastolic function in aged mice, enhancing heart health.
Cardiac NAD+ levels were significantly lower in aged mice, correlating with diastolic dysfunction and increased cell cycle inhibitors.
Assessment using NAD+ precursors like nicotinamide riboside over two months led to notable improvements in cardiac function.
These findings support the role of NAD+ metabolism in aging and heart failure, indicating potential for future therapies.