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September 10, 2025eLifeOpen Access

Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

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Authors

WGWesley H. GodfreyJLJudy LeeSSShruthi Shanmukha

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Overview

This study reveals PGAM's role in regulating Treg differentiation through serine synthesis and one-carbon metabolism.

Key Points

  • Phosphoglycerate mutase inhibition reduces Treg differentiation, increasing T helper 17-like markers.
  • Blocking de novo serine synthesis reverses PGAM inhibition effects, highlighting its role in Treg polarization.
  • Altering serine levels in vivo enhances peripheral Tregs and reduces autoimmunity in a model of multiple sclerosis.
  • Inhibiting one-carbon metabolism promotes Treg polarization and function both in vitro and in vivo.

Cite This Study

Godfrey et al. (2025) studied this question.

synapsesocial.com/papers/68c2409bb210217d6479addchttps://doi.org/10.7554/elife.104423.3
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