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October 8, 2025Global Cardiology Science and PracticeOpen Access

Expression of Toll-Like Receptor-2 and -4 in Normal Human Valves and Dysregulated Expression in Valves from Rheumatic Heart Disease Patients

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Authors

NLNajma LatifPSPadmini SarathchandraAMAnn McCormack

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Overview

Observational analysis highlights reduced TLR2 and TLR4 in RHD leaflets, indicating possible inflammation regulation.

Key Points

  • Reduced expression of TLR2 and TLR4 in RHD leaflets suggests altered immune response.
  • Aortic RHD leaflets showed TLR4 expression reduced significantly by p=0.0007 compared to normal leaflets.
  • Immunohistochemistry and flow cytometry were used to assess TLR expression in valve leaflets from patients.
  • Findings indicate potential compensatory mechanisms limiting inflammation in RHD patients.

Cite This Study

Latif et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1c76950a706b22b5f76https://doi.org/10.21542/gcsp.2025.hvbte.62
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Persistent Immunopathological Activity in Excised Valves from Rheumatic Heart Disease Patients in an Egyptian Cohort2025
  2. 2Inflammation in mitral stenosis due to rheumatic heart disease: a genetic and histological study2025
  3. 3Clinical significance and regulatory mechanism of miR-134-5p in rheumatic heart disease2025 · 2 citations
  4. 4Abstract Thu114: TRPV4 Contributes to Valve Stiffening, Cell Heterogeneity, and Transcriptional Reprogramming in Aortic Valve Stenosis2025
  5. 5Identification of therapeutic targets for rheumatic heart valve disease based on systematic druggable genome wide Mendelian randomization2025