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October 8, 2025Global Cardiology Science and PracticeOpen Access

Persistent Immunopathological Activity in Excised Valves from Rheumatic Heart Disease Patients in an Egyptian Cohort

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Authors

MRMohamed RoshdyAKArwa KohelaAIAyman M. Ibrahim

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Overview

The analysis demonstrates T-lymphocyte infiltration in valvular tissue, suggesting ongoing immune activity and gender differences in rheumatic heart disease.

Key Points

  • Infiltration of CD4⁺ and CD8⁺ T lymphocytes indicates ongoing immune activity in heart valves, impacting treatment.
  • Quantitative analysis showed greater CD4⁺ and CD8⁺ infiltration in mitral valves compared to aortic valves, suggesting location-specific responses.
  • Immunohistochemical staining revealed significant gender-specific differences, with typically higher T-cell counts in females' valve tissue.
  • These findings enhance understanding of immune mechanisms in rheumatic heart disease, aiding potential targeted therapeutic strategies.

Cite This Study

Roshdy et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1c76950a706b22b5f9ahttps://doi.org/10.21542/gcsp.2025.hvbte.48
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structural Remodeling in Rheumatic Heart Disease: Influence of Age and Gender in an Egyptian Cohort2025
  2. 2Expression of Toll-Like Receptor-2 and -4 in Normal Human Valves and Dysregulated Expression in Valves from Rheumatic Heart Disease Patients2025
  3. 3Inflammation in mitral stenosis due to rheumatic heart disease: a genetic and histological study2025
  4. 4Valvular aspects of echocardiography in rheumatic heart disease2025
  5. 5Rheumatic Heart Disease2026