Abstract Thu114: TRPV4 Contributes to Valve Stiffening, Cell Heterogeneity, and Transcriptional Reprogramming in Aortic Valve Stenosis

View Full Paper

Ask AI

Bookmark

Authors

Discussion

This analysis reveals that TRPV4 impacts matrix stiffness and cellular behavior in aortic valve stenosis, suggesting potential therapeutic targets.

TRPV4 contributes to increased stiffness in aortic valve tissues, highlighting its role in aortic valve stenosis.
Expression levels of TRPV4, CD68+ macrophages, and alpha-SMA+ myofibroblasts were significantly higher in aortic valve stenosis patients than in healthy controls.
Using a murine model demonstrated that TRPV4 deficiency resulted in significantly reduced valve stiffness after a high-fat diet.
Single-nucleus RNA sequencing revealed that TRPV4 regulates transcriptional dynamics across multiple cell types in aortic valve tissues.

Rahaman et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

View Full Paper

Ask AI

Bookmark

Authors

This analysis reveals that TRPV4 impacts matrix stiffness and cellular behavior in aortic valve stenosis, suggesting potential therapeutic targets.

TRPV4 contributes to increased stiffness in aortic valve tissues, highlighting its role in aortic valve stenosis.
Expression levels of TRPV4, CD68+ macrophages, and alpha-SMA+ myofibroblasts were significantly higher in aortic valve stenosis patients than in healthy controls.
Using a murine model demonstrated that TRPV4 deficiency resulted in significantly reduced valve stiffness after a high-fat diet.
Single-nucleus RNA sequencing revealed that TRPV4 regulates transcriptional dynamics across multiple cell types in aortic valve tissues.

Rahaman et al. (2025) studied this question.

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark