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September 10, 2025BMC Cardiovascular DisordersOpen Access

Clinical significance and regulatory mechanism of miR-134-5p in rheumatic heart disease

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Authors

LYLin YangJLJuan LiJWJu Wang

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Overview

This study evaluates miR-134-5p's diagnostic value and its association with RHD severity, suggesting new management approaches.

Key Points

  • Upregulated miR-134-5p levels correlate with increased rheumatic heart disease severity, indicating a potential biomarker.
  • The study found that low miR-134-5p levels are associated with better prognosis in patients suffering from RHD.
  • Using qRT-PCR and Kaplan-Meier survival analysis, this research examines the diagnostic and prognostic significance of miR-134-5p.
  • MiR-134-5p's regulation of inflammation in valvular interstitial cells demonstrates its potential role in managing rheumatic heart disease.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a4a4bhttps://doi.org/10.1186/s12872-025-05086-9
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Also Consider

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  1. 1miR-3150b-3p Promotes Vascular Smooth Muscle Cell Injury by Targeting ARL5B2025
  2. 2miR-146b-5p serves as a novel biomarker for acute myocardial infarction and is involved in regulating oxidized low-density lipoprotein-induced endothelial injury through targeting PRKAR2A2026
  3. 3Identification of therapeutic targets for rheumatic heart valve disease based on systematic druggable genome wide Mendelian randomization2025
  4. 4Expression profiles and bioinformatic analysis of circular RNA in rheumatic heart disease: potential hsa_circ_0001490 and hsa_circ_0001296 as a diagnostic biomarker2025
  5. 5Expression of Toll-Like Receptor-2 and -4 in Normal Human Valves and Dysregulated Expression in Valves from Rheumatic Heart Disease Patients2025