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October 5, 2025PLoS ONEOpen Access

Revealing the molecular mechanisms underlying Xuebijing against sepsis and septic acute kidney injury via bioinformatics and experimental approaches

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Authors

XLXing LiKRKe RenMBMatúš Baran

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Overview

Network pharmacology reveals Xuebijing's effects on sepsis and acute kidney injury, suggesting an anti-inflammatory mechanism.

Key Points

  • Xuebijing significantly reduced inflammatory markers IL-1β, IL-6, and TNFα in kidney cells, indicating its therapeutic potential.
  • Network pharmacology identified five key targets, including MMP9 and TNF, linking Xuebijing to its effects on sepsis and septic-AKI.
  • Molecular docking suggested high affinity of Xuebijing's components for MMP9 and TNFα, underscoring its anti-inflammatory action.
  • In vitro experiments confirmed Xuebijing's ability to suppress inflammatory signaling pathways associated with acute kidney injury.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68e24e6fd6d66a53c2473bdahttps://doi.org/10.1371/journal.pone.0333478
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