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August 19, 2025Scientific ReportsOpen Access

Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Guben Xiezhuo decoction against renal fibrosis

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Authors

SCShutao ChenYLYue LiuZLZhu Liwei

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Overview

Network pharmacology reveals Guben Xiezhuo decoction's effects on renal fibrosis in chronic kidney disease, suggesting potential therapeutic pathways.

Key Points

  • Guben Xiezhuo decoction significantly reduces renal fibrosis in a rat model, enhancing recovery from chronic kidney disease.
  • The study identified 14 active components linked to renal protection and 276 potential target proteins in GBXZD treatment.
  • An in vitro model demonstrated that GBXZD's components improved cell viability and reduced fibrosis markers in kidney cells.
  • Pathway analysis indicates GBXZD may inhibit fibrosis through the EGFR and MAPK signaling pathways.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af35d5cf1dd9ea359e9a10https://doi.org/10.1038/s41598-025-16012-6
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