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October 3, 2025Current Cancer Drug Targets

Comprehensive Immune Subtyping and Multi-Omics Profiling of the Tumor Microenvironment in Colorectal Cancer: Implications for Prognosis and Personalized Immunotherapy

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Authors

BZBailing ZhouZLZhiwei LiSFShengxian Fan

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Overview

Analysis identifies immune subtypes and a prognostic model in colorectal cancer, suggesting personalized immunotherapy strategies.

Key Points

  • Four immune subtypes were identified in colorectal cancer, indicating varying prognoses and treatment responses.
  • A prognostic risk model categorized patients into high- and low-risk groups based on TME-related gene expression.
  • ScRNA-seq analysis revealed distinct cellular interactions across immune subtypes, crucial for understanding tumor behavior.
  • Integration of microbial profiling indicated the role of microbial diversity in cancer progression and immune response.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68e040eda99c246f578b3453https://doi.org/10.2174/0115680096395386250910130110
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Also Consider

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  1. 1Single-cell technology reveals the crosstalk between tumor cells and immune cells: driving immune signal transduction and inflammation-mediated cardiac dysfunction in the tumor microenvironment of colorectal cancer2025 · 7 citations
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  3. 3Abstract P19: Profiling of Colorectal Cancer Tumor Microenvironment using Spatial Multi-Omics2025
  4. 4Immune–Metabolic Profiling Reveals Functional Heterogeneity Within Colorectal Cancer Consensus Molecular Subtypes2026
  5. 5Cellular characteristics of the immune microenvironment of colorectal cancer and progress in immunotherapy research2025 · 2 citations