Less invasive surfactant administration versus intubationsurfactant- extubation: a single-center retrospective study

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Retrospective study shows less invasive surfactant administration reduces intubation needs in preterm infants with RDS, suggesting improved outcomes.

LISA significantly reduced the need for intubation and mechanical ventilation within 72 hours compared to InSurE.
The LISA group had an intubation rate of 18% versus 64% in the InSurE group, with a relative risk of 0.28.
This retrospective observational study spanned five years, involving preterm neonates with RDS at 24-34 weeks' gestation.
LISA demonstrated benefits in reducing invasive ventilation duration, although no significant differences were observed in secondary outcomes.

CS et al. (2025) studied this question.

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View Full Paper

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Authors

Retrospective study shows less invasive surfactant administration reduces intubation needs in preterm infants with RDS, suggesting improved outcomes.

LISA significantly reduced the need for intubation and mechanical ventilation within 72 hours compared to InSurE.
The LISA group had an intubation rate of 18% versus 64% in the InSurE group, with a relative risk of 0.28.
This retrospective observational study spanned five years, involving preterm neonates with RDS at 24-34 weeks' gestation.
LISA demonstrated benefits in reducing invasive ventilation duration, although no significant differences were observed in secondary outcomes.

CS et al. (2025) studied this question.

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