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September 10, 2025Pediatric Pulmonology

Comparison of Bovine Lipid Extract Surfactant and Poractant Alfa Administered via LISA in Preterm Infants(28+0 to 34+6 Week) With Respiratory Distress Syndrome: A Randomized Controlled Trial

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Authors

AZAshadur ZamalMSMd Habibullah SkBSBijan Saha

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Overview

Randomized trial finds similar effectiveness for bovine and porcine surfactants in RDS, suggesting cost savings.

Key Points

  • No significant difference in intubation rates within 72 hours between BLES and poractant alfa.
  • Cost of bovine lipid extract surfactant was significantly lower at INR 20,539 compared to INR 29,677 for poractant alfa.
  • Both surfactants indicated similar clinical outcomes in managing respiratory distress syndrome in infants.
  • Study conducted over a year in a level 3 neonatal intensive care unit in India, with 282 preterm infants enrolled.

Cite This Study

Zamal et al. (2025) studied this question.

synapsesocial.com/papers/68d413f8713b0b5dfea61aeahttps://doi.org/10.1002/ppul.71281
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