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September 10, 2025The Journal of Perinatal & Neonatal Nursing

A Systematic Review: Is LISA as Effective as Endotracheal Tube Surfactant Administration in Reducing Bronchopulmonary Dysplasia in Preterm Infants?

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Authors

LYLauren YatesJCJ.M. CollarBWB. Wade

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Overview

Systematic review evaluates LISA and endotracheal surfactant administration on BPD in preterm infants, suggesting implications for ventilation methods.

Key Points

  • No significant difference was found in BPD rates between LISA and endotracheal surfactant administration, but LISA showed reduced intubation-related risks.
  • In a review of 58 studies involving between 26 and 7533 preterm infants, 43 found no difference in BPD incidence while 15 indicated lower rates with LISA.
  • The systematic review assessed studies comparing LISA with INSURE and mechanical ventilation concerning BPD outcomes across multiple databases.
  • The findings highlight potential benefits of LISA, including fewer ventilation days and lower intubation rates, but suffered from limitations like retrospective bias and small sample sizes.

Cite This Study

Yates et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d6479005ahttps://doi.org/10.1097/jpn.0000000000000939
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Less invasive surfactant administration versus intubationsurfactant- extubation: a single-center retrospective study2025
  2. 2Factors Associated with Intubation After Less Invasive Surfactant Administration (LISA); A Single-Center Cohort from Saudi Arabia2025
  3. 3Comparison of Bovine Lipid Extract Surfactant and Poractant Alfa Administered via LISA in Preterm Infants(28<sup>+0</sup> to 34<sup>+6</sup> Week) With Respiratory Distress Syndrome: A Randomized Controlled Trial2025
  4. 4Effectiveness of A Respiratory Care Protocol Including Less Invasive Surfactant Administration in ≥ 35 Weeks Gestational Age Infants.2025
  5. 5A randomized controlled equivalence trial of pulmonary surfactant administration via laryngeal mask airway versus endotracheal intubation2025