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August 15, 2025International Journal of PediatricsOpen Access

Tiny Lungs, Big Decisions: A Meta‐Analysis Comparing Minimally Invasive Surfactant Therapy Versus Intubation–Surfactant–Extubation in Preterm Neonates With Respiratory Distress Syndrome

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Authors

FBF. BurgosGMGeovanna Minchalo-OchoaSBSagrario Balda

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Overview

Meta-analysis finds minimally invasive surfactant therapy reduces complications in preterm neonates with respiratory distress syndrome, suggesting it may be preferred over intubation.

Key Points

  • Minimally invasive surfactant therapy reduced the risk of complications compared to the intubation-surfactant-extubation approach for preterm neonates.
  • The meta-analysis included 17 studies with 1931 preterm neonates, revealing that MIST reduced bronchopulmonary dysplasia and intraventricular hemorrhage risks significantly.
  • Observational cohorts and randomized controlled trials highlighted MIST's effectiveness, linking it to shorter mechanical ventilation times and reduced oxygen needs.
  • These findings imply that minimally invasive surfactant therapy may offer safer outcomes for infants with respiratory distress syndrome after delivery.

Cite This Study

Burgos et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64771d25https://doi.org/10.1155/ijpe/8045343
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Less invasive surfactant administration versus intubationsurfactant- extubation: a single-center retrospective study2025
  2. 2A randomized controlled equivalence trial of pulmonary surfactant administration via laryngeal mask airway versus endotracheal intubation2025
  3. 3SurfON trial: study protocol for a multicentre, open-label, randomised controlled trial of early surfactant therapy versus expectant management in late preterm and early term infants with respiratory distress2025
  4. 4Comparative effectiveness of various modes of non-invasive respiratory support in preterm infants with respiratory distress syndrome2025
  5. 5A Systematic Review: Is LISA as Effective as Endotracheal Tube Surfactant Administration in Reducing Bronchopulmonary Dysplasia in Preterm Infants?2025