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October 3, 2025BiologyOpen Access

Short- and Long-Term Effects of Undernutrition During Adolescence on Oxidative Status and Glucose Homeostasis in Male and Female Rats

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Authors

JPJoskame Saint PaulARAna Filipa D Castilho M RibeiroAKAna Caroline Schoenberger Kipper

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Overview

Study demonstrates that undernutrition impacts glucose homeostasis and oxidative stress in male and female rats, suggesting long-term health risks.

Key Points

  • Undernutrition during adolescence leads to changes in glucose homeostasis, observed in both male and female rats at 120 days.
  • At 60 days of age, undernourished rats showed high insulin sensitivity, but by 120 days, males exhibited an obese phenotype with lingering insulin sensitivity.
  • Increased GSH levels were noted in the liver as a short-term response, with gender differences observed in long-term iBAT redox status.
  • This research highlights the serious implications of adolescent undernutrition for future metabolic health in rats, with particular effects on male rats.

Cite This Study

Paul et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa2742https://doi.org/10.3390/biology14101352
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