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October 3, 2025Combinatorial Chemistry & High Throughput Screening

Uncovering ShuangZi Powder's Anti-Ovarian Cancer Mechanism: A Systems Biology and Experimental Approach

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Authors

WGWangang GongHYHong YaoWDWumin Dai

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Overview

Systems biology approaches reveal Shuangzi Powder's impact on the tumor microenvironment and immune checkpoints in ovarian cancer treatment.

Key Points

  • Shuangzi Powder significantly affects ovarian cancer treatment through multi-target mechanisms and pathways.
  • Among 11 bioactive ingredients, DMAS notably inhibited A2780 cell viability and migration, enhancing PD-L1 expression.
  • The study utilized systems biology, integrating molecular docking and experimental approaches for pharmacological insights.
  • Findings highlight the critical roles of the PI3K-Akt signaling pathway and apoptosis in Shuangzi Powder's therapeutic effects.

Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa23d0https://doi.org/10.2174/0113862073394765250828100829
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