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October 3, 2025npj Antimicrobials and ResistanceOpen Access

Relating antimicrobial use to wastewater resistance gene patterns via metagenomic analysis of two neighboring treatment plants circa the COVID-19 pandemic

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Authors

AMAyella Maile-MoskowitzCBConnor BrownMRMonjura Afrin Rumi

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Overview

Metagenomic analysis uncovers relationships between antimicrobial use and antibiotic resistance genes, revealing patterns in wastewater during the COVID-19 pandemic.

Key Points

  • Higher unique antibiotic resistance gene diversity was noted in community wastewater treatment plants compared to university sites, indicating different resistance profiles.
  • As prescriptions of antibiotics surged in 2022 in the university area, profiles of antibiotic resistance genes began to converge between the two treatment plants.
  • Wastewater metagenomic analysis explored antibiotic resistance in sewage and linked it to COVID-19 and changes in antimicrobial use.
  • Finding that reductions in antibiotic resistance gene levels were not immediately apparent suggests that time is needed post-intervention for signals to decrease.

Cite This Study

Maile-Moskowitz et al. (2025) studied this question.

synapsesocial.com/papers/68e02f2cf0e39f13e7fa1f8ahttps://doi.org/10.1038/s44259-025-00153-9
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Also Consider

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