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September 10, 2025Ecotoxicology and Environmental SafetyOpen Access

Resistomic features and novel genetic element identified in hospital wastewater with short- and long-read metagenomics

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Authors

MZManyi ZhangYXY XuSWShuyao Wang

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Overview

Metagenomic analysis reveals extensive antibiotic resistance genes in hospital wastewater, highlighting public health risks.

Key Points

  • The study finds that hospital wastewater contains a concerning reservoir of antimicrobial resistance genes.
  • It identifies 175 antibiotic resistance gene subtypes linked to 38 antimicrobials, including last-resort antibiotics.
  • Mobile genetic elements were shown to strongly associate with antibiotic resistance genes, indicating high dissemination potential.
  • With 85% of metagenome-assembled genomes carrying resistance genes, this highlights the prevalent resistance in wastewater.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478a703https://doi.org/10.1016/j.ecoenv.2025.118991
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