Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 3, 2025Methods and ProtocolsOpen Access

Antidepressant and Related Neurobiological and Neurophysiological Effects of Add-On Transcranial Direct Current Stimulation in Major Depressive Disorder with Residual Symptoms: A Randomized, Double-Blind Clinical Trial Protocol

View Full Paper
Ask AI
Bookmark
Share

Authors

CCCarmen ConcertoUniversity of CataniaFBFabrizio BellaUniversity of CataniaCCCecilia ChiarenzaGhent University Hospital

Discussion

Loading...

Member takes

Overview

Randomized trial evaluates effects of add-on tDCS on depressive symptoms in adults, suggesting neuroplastic benefits.

Key Points

  • Active tDCS significantly reduces depressive symptoms, with indication of neurobiological changes over time.
  • Primary outcome assessed using Hamilton Depression Rating Scale-17, aiming for remission defined as HDRS-17 ≤ 7.
  • Randomized double-blind placebo-controlled trial involving adult outpatients on stable SSRI treatment for MDD.
  • Program highlights potential for tDCS to improve cognitive performance and alter serum biomarkers linked to depression.

Cite This Study

Concerto et al. (2025) studied this question.

synapsesocial.com/papers/68e02f2cf0e39f13e7fa1dechttps://doi.org/10.3390/mps8050117
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Personalized High-Definition Transcranial Direct Current Stimulation for the Treatment of Depression2025
  2. 2Home-based non-invasive brain stimulation for treatment-resistant depression2025
  3. 3272. EFFECTIVENESS OF TRANSCRANIAL PULSE STIMULATION FOR MAJOR DEPRESSION: PRELIMINARY EVIDENCE FOR CLINICAL RESPONSE AND NEUROIMAGING MECHANISMS2025
  4. 4Therapeutic response of Transcranial Direct Current Stimulation (tDCS) in Attention Deficit Hyperactivity Disorder (ADHD): a study protocol for a parallel, randomized, double-blinded, single-center trial (Preprint)2025
  5. 5The effect of anodal transcranial direct current stimulation on affective impulsivity in methamphetamine users: A randomized experimental study2025