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August 1, 2025The International Journal of NeuropsychopharmacologyOpen Access

Effectiveness of Transcranial Pulse Stimulation for Major Depression: Preliminary Evidence for Clinical Response and Neuroimaging Mechanisms

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Authors

PQPenny Ping QinHong Kong Polytechnic UniversityWCWilkin ChauHong Kong Polytechnic UniversityICIvan K.Y. Chak

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Implication

Randomized controlled trial shows transcranial pulse stimulation improves symptoms in major depression, indicating promising therapeutic potential.

Key Points

  • Transcranial pulse stimulation significantly reduced depressive symptoms in patients with major depressive disorder, indicating its potential efficacy.
  • Participants receiving active treatment showed a greater reduction in MADRS scores (12.86) compared to the sham group (6.77), underscoring treatment effectiveness.
  • Observational analysis using rs-fMRI revealed enhanced functional connectivity between lDLPFC and MPFC post-treatment in the active group, indicating neurobiological changes.
  • The findings support the feasibility of conducting randomized controlled trials on transcranial pulse stimulation for major depression and highlight its therapeutic promise.

Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/68af2ee5cf1dd9ea359e67b7https://doi.org/10.1093/ijnp/pyaf052.036
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1602. RESEARCH ON TRANSCRANIAL PULSE STIMULATION (TPS) IN MAJOR DEPRESSIVE DISORDER (MDD)2025
  2. 2New therapeutic option for treatment-resistant depression using transcranial pulse stimulation: real-world data from a case series2025
  3. 3Transcranial Pulse Stimulation (TPS) suitable add-on treatment of patients with psychiatric disorders?2025
  4. 4Antidepressant and Related Neurobiological and Neurophysiological Effects of Add-On Transcranial Direct Current Stimulation in Major Depressive Disorder with Residual Symptoms: A Randomized, Double-Blind Clinical Trial Protocol2025 · 1 citations
  5. 5Comparison of the clinical efficacy of rhythmic transcranial magnetic stimulation protocols in patients with depression2025