September 10, 2025Open Access

Therapeutic response of Transcranial Direct Current Stimulation (tDCS) in Attention Deficit Hyperactivity Disorder (ADHD): a study protocol for a parallel, randomized, double-blinded, single-center trial (Preprint)

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Randomized trial examines the efficacy of bifrontal tDCS on ADHD symptoms in adults, suggesting it may be a suitable alternative to lisdexamfetamine.

Active transcranial direct current stimulation (tDCS) is expected to significantly reduce ADHD symptoms across multiple domains.
The primary outcome measures a decrease in ADHD severity, indicated by scoring from the ADHD Rating Scale pre- and post-treatment.
This randomized controlled trial involves 156 ADHD adults, assessing the safety and efficacy of tDCS combined with lisdexamfetamine.
Results may encourage considering tDCS as a viable therapeutic option alongside or instead of traditional stimulant medications.

J. Pires (2025) studied this question.

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Randomized trial examines the efficacy of bifrontal tDCS on ADHD symptoms in adults, suggesting it may be a suitable alternative to lisdexamfetamine.