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September 12, 2025JAMA Network OpenOpen Access

Personalized High-Definition Transcranial Direct Current Stimulation for the Treatment of Depression

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Authors

MJMayank JogVNVera NorrisUniversity of California, Los AngelesPPPaloma PfeifferUniversity of California, Los Angeles

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Implication

Randomized controlled trial improved mood in patients with moderate to severe depression, highlighting potential for personalized tDCS therapy.

Key Points

  • Active HD-tDCS therapy significantly improved mood in patients, with a group difference in HAMD score of -2.2.
  • Seventy-one participants were randomized to receive either active or sham HD-tDCS over 12 days, showing greater improvement in the treatment group.
  • The study utilized neuronavigation to precisely personalize stimulation parameters, enhancing treatment efficacy.
  • Follow-up studies are needed to explore the long-term effects and potential of HD-tDCS for treating anxiety disorders.

Cite This Study

Jog et al. (2025) studied this question.

synapsesocial.com/papers/68d41bfb713b0b5dfea6508bhttps://doi.org/10.1001/jamanetworkopen.2025.31189
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