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October 2, 2025Indonesian Journal of BiotechnologyOpen Access

Network pharmacology‐based exploration of gut microbiota‐derived metabolites for type‐2 diabetes

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Authors

NWNadia WidjajaSSStefeny Theresia SimatupangSTSanti Tan

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Overview

This analysis identifies gut microbiota-derived metabolites that may alleviate type-2 diabetes, suggesting novel therapeutic strategies.

Key Points

  • Quercetin and daidzein show potential antidiabetic effects through specific gut microbiota metabolites and protein targets.
  • The study identifies critical proteins, AKT1 and EGFR, involved in insulin signaling pathways related to type-2 diabetes.
  • Molecular docking analysis validated the binding strengths of metabolites to insulin signaling-related genes.
  • 10-oxo-11-octadecenoic acid and 10-keto-12Z-octadecenoic acid may regulate insulin signaling through the PPARG gene.

Cite This Study

Widjaja et al. (2025) studied this question.

synapsesocial.com/papers/68de796d5b556a9128e1ac7bhttps://doi.org/10.22146/ijbiotech.107382
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gut microbiota as a key player in type 2 diabetes: Current perspectives2025
  2. 2Role of gut microbiota in Type 2 diabetes mellitus2025
  3. 3Bioactive Metabolites from Yeasts Presumptively Qualified as Safe as Functional Agents in the Management of Type 2 Diabetes2025
  4. 4Managing Glucose Homeostasis Through the Gut Microbiome2025
  5. 5Integrative analysis of gut microbiota and metabolic pathways reveals key microbial and metabolomic alterations in diabetes2025