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September 10, 2025Scientific ReportsOpen Access

Integrative analysis of gut microbiota and metabolic pathways reveals key microbial and metabolomic alterations in diabetes

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Authors

YMYasser MorsyNSNesma S. ShafieMMMohamed Mostafa

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Overview

Analysis reveals significant differences in gut microbiota and metabolic pathways in diabetic individuals, indicating potential therapeutic targets.

Key Points

  • Diabetes is associated with significant alterations in gut microbiome composition and function, affecting metabolic pathways.
  • Microbial diversity was higher in the diabetic group, with increased Bacteroidaceae and Lachnospiraceae, suggesting impacts on metabolic regulation.
  • Metabolomic analyses indicated disruptions in fatty acid metabolism and glucose homeostasis linked to gut microbiota changes.
  • Pathway enrichment analysis identified key metabolic alterations that could serve as biomarkers for diabetic treatments.

Cite This Study

Morsy et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a4fd4https://doi.org/10.1038/s41598-025-09328-w
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