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September 18, 2025Annual Review of Physiology

Managing Glucose Homeostasis Through the Gut Microbiome

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Authors

SWSavanna N. WeningerAMAndrew ManleyFDFrank A. Duca

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Overview

This review highlights the gut microbiota's influence on type 2 diabetes, suggesting prebiotics and probiotics as potential treatments.

Key Points

  • The gut microbiota significantly contributes to the development of type 2 diabetes mellitus (T2D) through metabolic interactions.
  • Targeting the gut microbiota with therapies like fecal microbiota transplant and prebiotics offers novel approaches to T2D management.
  • Understanding the relationship between gut microbiota and diabetes could lead to effective alternative treatments for metabolic diseases.
  • The influence of diet on gut microbiota further emphasizes the potential for dietary interventions in managing T2D.

Cite This Study

Weninger et al. (2025) studied this question.

synapsesocial.com/papers/68d433a3713b0b5dfea72b46https://doi.org/10.1146/annurev-physiol-051524-094728
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gut microbiota as a key player in type 2 diabetes: Current perspectives2025
  2. 2Role of gut microbiota in Type 2 diabetes mellitus2025
  3. 3The Role of Gut Microbiota in Modulating Inflammation and Insulin Resistance in Type 2 Diabetes Mellitus: Implications for Complication Management2025
  4. 4Type 2 Diabetes and the Multifaceted Gut-X Axes2025
  5. 5Gut Microbiota and Metabolites: Biomarkers and Therapeutic Targets for Diabetes Mellitus and Its Complications2025