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October 11, 2025Journal of Applied Pharmaceutical ScienceOpen Access

Gut microbiota as a key player in type 2 diabetes: Current perspectives

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Authors

SSSruthi SethumadhavanSJSaiju JacobMBM. Babu

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Overview

Mini review highlights gut microbiota's role in influencing glucose metabolism in type 2 diabetes, suggesting microbiome-targeted therapies.

Key Points

  • Individuals with type 2 diabetes often exhibit an altered firmicutes/bacteroidetes ratio and microbial imbalance, leading to impaired glucose metabolism.
  • Antidiabetic drugs can modulate the gut microbiome, highlighting a bidirectional relationship that may influence treatment efficacy.
  • Incorporating prebiotics and probiotics into treatment regimens shows potential in restoring microbial balance and improving insulin sensitivity.
  • Research indicates pharmacomicrobiomics may predict drug response and side effects based on individual microbial profiles.

Cite This Study

Sethumadhavan et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1c1ba7d64b6fc1323f4https://doi.org/10.7324/japs.2026.267236
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of gut microbiota in Type 2 diabetes mellitus2025
  2. 2Managing Glucose Homeostasis Through the Gut Microbiome2025 · 1 citations
  3. 3The Role of Gut Microbiota in Modulating Inflammation and Insulin Resistance in Type 2 Diabetes Mellitus: Implications for Complication Management2025 · 2 citations
  4. 4Gut Microbiota and Metabolites: Biomarkers and Therapeutic Targets for Diabetes Mellitus and Its Complications2025 · 11 citations
  5. 5From Metformin to Microbiome: The Missing Links in Metabolic Modulation2025